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Project PRISM
Are you interested in reducing your cannabis use and depression?
Join our online clinical trial being conducted at Massachusetts General Hospital and Harvard Medical School
What is AMP-C?
Project PRISM is a randomized controlled trial evaluating a self-guided digital therapeutic: (DTx) Amplification of Positivity – Cannabis Use Disorder (AMP-C). This DTx was designed to target reward dysfunction, a common deficit in those with both Cannabis Use Disorder (CUD) and Major Depressive Disorder (MDD). AMP-C was developed in collaboration with individuals who have lived experiences with cannabis use and depression symptoms. We hope that this study will provide us with information on the efficacy of AMP-C and guide the development of more effective, scalable methods for treating co-occurring CUD and MDD.
Amplification of Positivity – Cannabis Use Disorder (AMP-C) is an app-based intervention that was designed by adapting an evidence-based psychotherapy, Amplification of Positivity, which has demonstrated efficacy in reducing substance use, depression, and anxiety. AMP-C includes several modules that focus on understanding the link between cannabis use and depressive symptoms and offer strategies to boost positive emotions. Each module of AMP-C includes 2-4 brief psychoeducation videos and activities. By engaging with AMP-C, you may develop adaptive skills to increase your positive emotions and behaviors while also decreasing your cannabis use and depressive symptoms.
Interested in participating in our study? Take this 5-minute survey to see if you are eligible to participate:
We are not recruiting participants at this time.
Cannabis Use Disorder
Cannabis Use Disorder (CUD) is a type of substance use disorder and mental health condition. It is marked by a problematic pattern of cannabis use that causes distress or difficulties in daily life. People with CUD may experience a strong urge to use cannabis, a tolerance to its effects, or withdrawal symptoms when trying to stop. CUD may interfere with your health, relationships and how you feel day to day.
Major Depressive Disorder
Major depressive disorder (MDD) is a type of mood disorder marked by lasting feelings of sadness and a reduced interest in once enjoyable activities. MDD is different than just experiencing sadness. People with MDD experience a range of symptoms that occur nearly every day for at least two weeks and can include difficulties sleeping and eating. People with MDD often experience difficulties with their daily functioning that may impact their work, home, or social lives.
As of 2023:
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25.9% of adults used marijuana in the past month
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7% of adults were diagnosed with having cannabis use disorder
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Among adults with cannabis use disorder, 52.5% of them had a co-occurring mental illness
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8.5% of adults had a major depressive episode in the past year
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Our Team
Dr. Amanda Collins
Principal Investigator
accollins@mgh.harvard.edu
Harvard Catalyst Profile
CV
Amanda C. Collins is a clinical psychologist and the Principal Investigator of Project PRISM. She is the Director of Digital Phenotyping and Therapeutics Research in the Depression Clinical and Research Program at Massachusetts General Hospital, and she is a Member of the Faculty in the Department of Psychiatry at Harvard Medical School.
Shirley Wu
Clinical Research Coordinator
Deano Izaguirre
Lab Volunteer
Ella Chase
Lab Volunteer
Heeya Ajwani
Lab Volunteer
Remy Mosaheb
Lab Volunteer
Our Partners
Funders
The National Institute on Drug Abuse (NIDA) is an institute within the National Institutes of Health (NIH). The NIDA is the largest supporter of research on substance use and addiction.
Collaborators
Dartmouth College is a private research university located in Hanover, New Hampshire.
